Elucidating Regulators of Stem Cell Differentiation and Cardiac Tissue Formation
A review of Sox1 is essential for the specification of cardiac mesoderm in embryonic
stem cells
Liu et al (2007) use gene expression analysis to show that the Wnt/β-catenin pathway is essential for cardiac myogenesis to occur in embryonic stem (ES) cells, acting at a gastrulation-like stage to mediate mesoderm formation and patterning (two prerequisites for cardiac myogenesis itself). Among the temporally associated genes identified by the research team was Sox17, which was found to encode an endodermal HMG-box transcription factor. Microarray analysis (using 22K mouse 60-mer arrays from Agilent, in part) of Wnt- and BMP-dependent genes in differentiating ES cells enabled the team to identify multiple early targets...
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Elucidating Regulators of Stem Cell Differentiation and Cardiac Tissue Formation
A review of
Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.
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