Mouse CGH Arrays
Mouse CGH Arrays
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The Agilent platform offers global coverage of native DNA with CGH-specific probes to identify regions of interest. Agilent’s SurePrint inkjet technology ensures high-precision feature placement through base-by-base synthesis and a robust QC process, resulting in superior quality microarrays. Agilent's catalog of CGH formats features predesigned, high-resolution microarrays that enable genome-wide survey and chromosomal profiling. Oligo aCGH probes are selected based on proprietary CGH-optimized algorithms, delivering increased data quality and reproducible aberration detection.
Oligo aCGH technology has enabled scientists to study chromosomal variation with greater accuracy, coverage, and sensitivity than ever before offering a sensitive and flexible alternative to traditional cytogenetic techniques. Oligonucleotide microarrays can enable you to detect large or focal amplifications and deletions, elucidate copy number boundaries within the genome, and characterize chromosomal variations, offering new perspectives on genetically-linked diseases and mechanisms of tumorigenesis. The use of mouse as a model system has enabled scientists to examine human diseases such as those related to cardiology, cancer, diabetes, behavioral disorders, and toxicology, without requiring human subjects during initial stages of drug and therapy development. These organisms have provided valuable information for elucidating disease pathology and mechanisms of regulatory control.
Figure 1. Typical probe coverage characteristics on Agilent 244A and 105A CGH microarrays as illustrated using UCSC hg18 Human Genome Browser, Feb 2006 (NCBI build 36) of chromosome 17.
At the top of each view, each short vertical bar represents a single probe on Agilent Human Genome CGH microarray 244A (blue) or 105A (red). Annotations below the probes indicate the location mapping of UCSC known genes (blue or black) and Sanger microRNAs (red).
Figure 2. CGH Analytics chromosome view (top) and zoomed-in gene view (bottom) of chromosome 3 in the human colon carcinoma cell line HT29.
Genomic variations include both gains and losses of chromosomal regions that often vary extensively in their sizes. The enhanced detection resolution enabled through the high-density microarrays delivers the highest precision in mapping chromosome breakpoints and identification of micro-variations that are not detected by other platforms. CGH Analytics chromosome view (panel A) and zoomed-in gene view (panel B) of chromosome 3 in the human colon carcinoma cell line HT29.
Title: High-Density CGH 244A and 105A Performance Showcase
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Mouse Genome CGH 244A: a high-resolution tool for genome-wide DNA variation profiling without amplification or complexity reduction that features comprehensive probe coverage spanning both coding and noncoding regions on a 244K array
For detailed specifications and ordering information visit agilent.com
Mouse Genome CGH 105A: a similar tool to the 244A array with the flexibility to run two samples on a single 105K chip, significantly reducing costs
For detailed specifications and ordering information visit agilent.com
Rat Genome CGH 244A: a high-resolution tool for genome-wide DNA variation profiling without amplification or complexity reduction that features comprehensive probe coverage spanning both coding and noncoding regions on a 244K array
For detailed specifications and ordering information visit agilent.com
Rat Genome CGH 105A: a similar tool to the 244A array with the flexibility to run two samples on a single 105K chip, significantly reducing costs
For detailed specifications and ordering information visit agilent.com